| 08.09.2021 | Panama City | Estadio Rommel Fernandez | 16 000 |
| Panama | 1:1 (1:0) | Mexico |
| [1] Luis Mejia, [16] Andres Andrade, [4] Fidel Escobar, [15] Eric Davis, [23] Michael Murillo, [8] Adalberto Carrasquilla, [20] Anibal Godoy(c), [19] Alberto Quintero, [7] Jose Luis Rodriguez, [10] Edgar Barcenas, [9] Rolando Blackburn | [13] Guillermo Ochoa(c), [2] Nestor Araujo, [3] Cesar Montes, [23] Jesus Gallardo, [5] Luis Romo, [16] Jorge Sanchez, [6] Jonathan dos Santos, [7] Orbelin Pineda, [8] Carlos Rodriguez, [17] Jesus Corona, [11] Rogelio Funes Mori |
| Coach:Thomas Christiansen (ESP) | Jorge Walter Theiler (ARG) |
| Scorers:28' Rolando Blackburn | 76' Jesus Corona |
| Substitutions:7' in [5] Abdiel Ayarza out Adalberto Carrasquilla, 46' in [21] Cesar Yanis out Alberto Quintero, 46' in [11] Eduardo Guerrero out Rolando Blackburn, 79' in [2] Cesar Blackman out Jose Luis Rodriguez, 88' in [6] Alfredo Stephens out Edgar Barcenas |
46' in [9] Henry Martin out Rogelio Funes Mori, 46' in [14] Sebastian Cordova out Jonathan dos Santos, 46' in [18] Andres Guardado out Carlos Rodriguez, 60' in [22] Uriel Antuna out Orbelin Pineda, 85' in [10] Rodolfo Pizarro out Jesus Corona |
| Cautions: |   |
| Referee:Mario Escobar (GUA) Fourth Official:Bryan Lopez (GUA) |
Assistant referee:Caleb Wales (TRI), Henry Pupiro (NCA) |