| 24.03.2022 | Ciudad del Este | Estadio Antonio Aranda | 10 000 |
| Paraguay | 3:1 (2:0) | Ecuador |
| [1] Antony Silva, [5] Fabian Balbuena, [15] Gustavo Gomez(c), [4] Blas Riveros, [2] Robert Rojas, [8] Richard Ortiz, [14] Andres Cubas, [20] Richard Sanchez, [10] Miguel Almiron, [19] Julio Enciso, [9] Robert Morales | [1] Hernan Galindez, [6] Byron Castillo, [7] Pervis Estupinan, [3] Piero Hincapie, [17] Angelo Preciado, [2] Felix Torres, [8] Carlos Gruezo, [15] Angel Mena, [20] Sebas Mendez, [10] Joao Rojas, [13] Enner Valencia(c) |
| Coach:Guillermo Barros Schelotto (ARG) | Gustavo Julio Alfaro (ARG) |
| Scorers:9' Robert Morales, 45'+6 Piero Hincapie(og), 54' Miguel Almiron | 85' Jordy Caicedo(p) |
| Substitutions:14' in [11] Angel Romero out Robert Morales, 66' in [23] Mathias Villasanti out Andres Cubas, 77' in [18] Josue Colman out Julio Enciso, 77' in [16] Jose Florentin out Richard Sanchez, 77' in [13] Alberto Espinola out Robert Rojas |
46' in [16] Jeremy Sarmiento out Joao Rojas, 46' in [5] Romario Ibarra out Angelo Preciado, 58' in [11] Michael Estrada out Enner Valencia, 76' in [23] Michael Carcelen out Sebas Mendez, 76' in [9] Jordy Caicedo out Angel Mena |
| Cautions:32' Miguel Almiron, 39' Blas Riveros, 43' Andres Cubas, 81' Gustavo Gomez, 88' Blas Riveros, 90'+1 Mathias Villasanti | 53' Enner Valencia, 72' Felix Torres |
| Expulsions:88' Blas Riveros |   |
| Referee:Jesus Valenzuela (VEN) Fourth Official:Jose Argote (VEN) |
Assistant referee:Jorge Urrego (VEN), Tulio Moreno (VEN) |